This Expert Panel believes that RYR-based food supplements and nutraceuticals may play a role in reducing the global burden of CV disease. An increased quality of food supplements and nutraceuticals is an essential requirement to ensure safety of the product and the protection of consumers.
A post-marketing surveillance must be mandatory for food supplements and nutraceuticals as it is for drugs; this will also help to collect data on long-term safety. Monacolin K at 3 mg/day appears to essentially and safely reduce LDL-C levels.