Publication at First Faculty of Medicine |
2019
Abstract
Cryoglobulinemia was found to be the most common extrahepatic manifestation of chronic hepatitis C virus (HCV) infection. Cryoglobulins are broad class of paraproteins which are able to precipitate in specific circumstances.
Cutaneous vasculitis is the most prevalent clinical sign of cryoglobulinemia. Directly acting antivirals represent the only causal therapeutical option.
Directly acting antivirals maybe administered in combination with rituximab and with plasmapheresis in life threatening condition. Recommendations regarding antiviral therapy in cryoglobulinemia are the same as in non-cryoglobulinemic HCV cases.
Hepatitis C virus cure is associated with clinical improvement in at least majority of cases.