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Temporal arteritis - pitfalls in diagnosis and treatment

Publication at First Faculty of Medicine |
2019

Abstract

Temporal arteritis is the most common form of systemic vasculitis in people over 50 years of age. It affects large and medium caliber arteries and is caused by the giant cell inflammation of the affected artery.

Temporal arteritis diagnostics is based mainly on the characteristic clinical manifestation, biopsy of the affected artery and in recent years the use of imaging methods is still gaining in importance. The main drug used in the treatment of temporal arteritis is high-dose glucocorticoids, if there is a lack of their effect, classical immunosuppressants - methotrexate, azathioprine, leflunomide, mycophenolate mofetil, hydroxychloroquine, dapson and cyclophosmamide are used.

Recently, there has been an increase in the use of new biological drugs, in particular, the IL-6 inhibitor tocilizumab, the inhibitor of IL-12/23 ustekinumab, CTLA-4 abatacept, or drugs of the JAK family.