The influence of psoriasis and metabolic syndrome on the level of systemic inflammation and oxidative stress
Abstrakt
Aim. To assess independent influence of psoriasis and metabolic syndrome on the level of systemic inflammation and oxidative stress.
Methods. Clinical examination, Biochemical tests, Enzyme Linked Immunosorbent Assay (ELISA), Enzyme Immunoassay (EIA).
Statistics. Group of persons with psoriasis divided into subgroups of persons with and without metabolic syndrome (n=42).
Control group (volunteers) divided into subgroups of persons with and without metabolic syndrome (n=80). Anderson-Darling normality test, Wilcoxon test, Bartlett test of variances homogeneity, Two-tail test, Wilcoxon rank sum test.
Assessed markers. Psoriasis Area Severity Index (PASI) score (marker of systemic inflammation).
Peripheral blood samples: calprotectin (marker of systemic inflammation), 8-hydroxy-2'-deoxyguanosine, 8-hydroxyguanosine, and 8-hydroxyguanine (markers of oxidative stress), waist circumference, fasting glucose, triglycerides, HDL cholesterol and blood pressure (markers of metabolic syndrome). Results and Conclusion.
Increased level of systemic inflammation (calprotectin; p<0.001) and oxidative stress (p<0.001) and relationship between PASI score and oxidative stress (rho=0.44, p<0.01) in the whole group of persons with psoriasis compared to the whole control group. Increased level of calprotectin (p<0.001) and oxidative stress (p<0.01) in the subgroup of persons with psoriasis and metabolic syndrome (compared to the subgroup of controls with metabolic syndrome).
Both, psoriasis and metabolic syndrome significantly increased the level of systemic inflammation and oxidative stress.