Abstract
Objective: The aim of this study was to analyse the cli-nical outcome of patients with diagnosis of leiomyoma with bizarre nuclei (LBN) undergoing uterus saving surgery due to fertility preservation.Design: Retrospective clinical study.Setting: Department of Obstetrics and Gynaecology, First Faculty of Medicine, Charles University, General University Hospital, Prague.Methods: This was a retrospective clinical study of pa-tients with LBN diagnosis after myomectomy between January 2002 and June 2017 which were searched in our database. The data were obtained from medical documentation and from correspondence with patients.Results: We identified 37 patients meeting the criteria in our database.
The median age of the patients was 34.0 years. 30 patients (81.1%) underwent laparoscopic procedure, 7 (18.9.%) had open myomectomy. The peri-operative appearance of fibroid was found normal in 27 cases (73.0%), in the rest the appearance was described somehow abnormal.
The follow-up data were obtained from 35 women; the median follow-up time was 48 months. 9 patients (25.7%) needed re-intervention for fibroids with 2 specimens (22.2%) classified as LBN again. The overall pregnancy rate was 63.6% and life birth rate was 33.3%.
We did not observe any distant recurrence of the disease or malignant recurrence or death related to the diagnosis.Conclusion: Uterus sparing surgery for treatment of LBN seems to be safe and reasonable therapy for women wishing to preserve fertilit