Combined use of galectin-3 and thyroid peroxidase improves the differential diagnosis of thyroid tumors
Abstrakt
The study was focused on the assessment of an expression of galectin-3 and thyroid peroxidase (TPO) in a large collection of 186 thyroid tumors, benign and malignant and their oncocytic and non-oncocytic variants. Oncocytic tumors remain controversial with a respect to their pathobiology, behavior and management.
The aim of this study was to evaluate the differential diagnostic/prognostic potential of both markers. In conclusion, the combined use of galectin-3 and TPO markers could help to improve the differential diagnosis of malignant thyroid tumors, whereas the use them as a single marker remains unsatisfactory.
Differences in expression of both markers between oncocytic and non-oncocytic variants is another argument for an explanation of their differing pathobiology and their separation in independent neoplastic entities.