Novel electrochemical DNA biosensor based on edge-plane pyrolytic graphite for DNA interaction studies
Abstract
Carbon electrodes represent the most popular working electrodes used in electrochemical analysis of nucleic acids. Since the end of the 20th century, they have been frequently used for a lot of various applications in the field of electrochemical analysis of DNA, RNA, as well as synthetic mimics of nucleic acids such as PNA.
Some of their remarkable properties enhanced their utilization as electrochemical transducers of sensors for DNA hybridization, DNA-drug interactions, or even monitoring DNA damage. The aim of the proposed study is the preparation, development, and subsequent testing of new electrochemical DNA biosensors based on relatively new type of carbon material "edge-plane" pyrolytic graphite (EPPG) and its subsequent utilization as a useful analytical tool.