Inherited C2-complement deficiency: variable clinical manifestation (case reports and review)

Abstract

C2 deficiency represents the most frequent type of a complement deficiency. Clinical manifestation includes infections caused by encapsulated bacteria (Streptococcus pneumoniae, Neisseria meningitidis) such as meningitis, gonitis, pneumonia or septicaemia.

A causative treatment has not been available yet A prophylactic vaccination and/or a long-term antibiotics prophylaxis are recommended.

Keywords

• complement system
• C2
• immunodeficiency
• meningitis
• pneumococcal disease
• vaccination