The Global Initiative for Asthma (GINA) report was primarily intended as a strategy document and not a clinical guideline. However, the 2014 update moved the report towards a "practical, clinical practice-centred document" and has in many countries formed a basis for national guidelines.
A possible limitation of the GINA report is its primary focus on evidence coming from randomized controlled trials, potentially leading to the omission of clinically important data coming from real-life and observational studies, and in conclusions based on highly selected asthmatic patients, fulfilling strict study inclusion criteria.