High-sensitivity troponin (troponin I and troponin T) is serum marker specific for myocardial injury. Raised high-sensitivity troponin levels can be found in acute coronary syndrome, but also in a variety of other conditions as well.
Differential diagnosis of high-sensitivity troponin elevations are a great challenge for emergency physicians. Apart from ruling-out acute coronary syndrome, other potential causes such as cardiovascular disease, infections, renal disease and age have to be considered.
This narrative review discusses the possible insight of an emergency physician on non-ischaemic elevations of high-sensitivity troponin with a focus on prognostic value of high-sensitivity troponin.