Charles Explorer logo
🇬🇧

Lymphoproliferation disease in HIV positive patients

Publication at First Faculty of Medicine |
2020

Abstract

Lymphomas that occur in HIV-positive people can be divided into two groups. The first includes lymphomas (AIDS related lymphoma - ARL), which are typically associated with HIV infection and which define the transition to aquired immunodeficiency syndrome (AIDS) in this infection.

The second group includes all other lymphomas, including Hodgkin's lymphoma. Combination antiretroviral therapy (cART), which can effectively stop HIV replication, has significantly improved the quality of life, immune function and life expectancy of HIV-positive patients.

At the same time, the incidence of some malignant diseases defining AIDS, particularly Kaposi's sarcoma, diffuse large cell lymphoma (DLBCL) and primary CNS lymphoma (PCNSL), has decreased. In contrast, the incidence of Hodgkin's lymphoma increases in HIV-positive patients with antiretroviral treatment duration.

For HIV positive lymphoma patients, who usually develop aggressive malignancies, rapid diagnosis of lymphoma and initiation of appropriate chemotherapy is extremely important. This article gives a brief overview of the clinical behavior and treatment ofthese diseases.