Photorefractive intrastromal corneal crosslinking (PiXL) for correction of hyperopia - 12 months results
Abstract
Purpose: To evaluate the efficacy of epithelium-on photorefractive intrastromal corneal cross-linking (PiXL), a novel, non-invasive procedure to reduce refractive error in patients with low hyperopia at twelve months follow up. Setting: Gemini Eye Clinic, Zlin, Czech Republic Design: Prospective single-center study Methods: 22 low hyperopic eyes were enrolled and underwent PiXL treatment according to a standardized treatment protocol.
Visual acuity, subjective distance refraction, keratometry, topography, pachymetry, subjective discomfort, and endothelial cell density were recorded during twelve months follow up. Results: Manifest refraction (MR) decreased significantly (p<0.0001) from +0.75 (+0.63 to +1.06, median and IRQ) D pre-operatively to +0.25 (0.0 to 0.50) at 12 months follow up and remained stable. 77% of eyes achieved refraction within +- 0.5 D of emmetropia by 1 month post-op and stable through 12 months follow up.
Endothelial cell density was stable and did not show significant changes. There was low incidence of post-operative pain and dry eyes.
Conclusions: PiXL is a promising alternative to conventional laser refractive surgeries for low hyperopia. Further studies are warranted to optimize treatment parameters for a wider range of refractive errors, and to evaluate the potential to improve precision.