Alcohol septal ablation for hypertrophic obstructive cardiomyopathy improves myocardial performance: A 24-month follow-up
Abstract
Alcohol septal ablation (PTSMA) improves outflow gradient, left ventricular (LV) diastolic function and symptoms in patients with hypertrophic obstructive cardiomyopathy (HOCM). Tei index (index of myocardial performance) is a parameter reflecting both systolic and diastolic LV function.
Thirty consecutive patients (mean age 54 +/- 14 years) with symptomatic HOCM underwent PTSMA procedure. Clinical and echocardiographic data were collected at baseline and 24 months after PTSMA.
Tei index was assessed as a sum of isovolumic contractile and relaxation times divided by LV ejection time. Time intervals were obtained with Doppler echocardiography.
During follow-up, Tei index decreased from 0.67 +/- 0.13 to 0.56 +/- 0.06. All analyzed patients reported relief of symptoms (2.6 +/- 0.7 versus 1.4 +/- 0.7 NYHA class; p +/- 0.01) and decrease of maximal outflow gradient (69 44 versus 11 +/- 11 mmHg; p < 0.01).
In summary, PTSMA is an effective method of therapy for HOCK The early shortening of Tei index suggests the improvement of LV myocardial performance.