Relation between ethanol dose and clinical outcomes in patients undergoing percutaneous septal ablation for obstructive hypertrophic cardiomyopathy: A prospective, randomized study
Abstrakt
This prospective, randomized study evaluates the association between ethanol dose and postprocedural hemodynamic, morphologic, and clinical changes in patients treated by alcohol septal ablation (PTSMA) for obstructive hypertrophic cardiomyopathy (HCM). Forty-four patients (24-75 yrs) undergoing PTSMA were randomized in 1:1 fashion to receive either 2 cc of ethanol (high dose, group 13).
Clinical, morphological, and hemodynamic data were obtained at baseline, immediately after procedure, and periodically up to 3 months after PTSMA. In both groups, there were significant improvements in symptom class, reduction in septal wall thickness, and relief of the left ventricular outflow tract gradient at three months of follow-up.
However, there were no differences in therapeutic efficacy according to the dose of the ethanol. These results suggest that the time course of the left ventricular pressure gradient relief and left ventricular remodeling was the same in both groups of patients and was not influenced by volume of ethanol injected.