Publikace na 2. lékařská fakulta |
2010
Abstrakt
Cancer is presently one of the most studied lifestyle disease. Its treatment is among others based on chemotherapy.
One of the drugs used in chemotherapy is doxorubicin, which interacts with DNA and inhibits division of tumour cells. For better usage of this compound as drug, it is necessary to know its interactions with DNA.
In work, interactions between doxorubicin and DNA were monitored using electrochemical methods. In addition, intarcalation of doxorubicin into DNA isolated from resistant as well as sentisive tumour cells was monitored and mutual correlation was searched.