The effect of two beta(2) adrenergic agonists on the ultrastructure of the airway epithelium in rabbits
1998
Abstrakt
The ultrastructure of the rabbit tracheal epithelium was studied 30 min after intratracheal administration of Ventolin (0.2 mg of salbutamol) and Berotec (0.4 mg of fenoterolhydrobromide), respectively. The injury to the tracheal epithelium due to the treatment with two puffs of Ventolin was considered moderate to severe and morphological signs of impaired self-cleaning ability were encountered.
After administration of a similar dose of Berotec, only a mild damage to this epithelium was revealed. Marked differences exist in the degree of damage to the airway epithelium due to the administration of two drugs that belong to the same family of the selective beta(2) adrenergic agonists.