Selected innovations in the prevention, diagnosis and treatment of HIV infection in the years 2019-2020
Abstract
AIDS (Acquired Immune Deficiency Syndrome) emerged in the half of 1981 and has already ended lives of nearly 40 million people around the world. Approximately the same number of infected people in different stages of the disease still lives.
Intense research of possible drugs is ongoing For the whole period, but we do not háve a medicine neither a vaccine that would be capable of curing the disease once and for all. Early lifetime treatment with efficacious antiretrovirals elaborated into a detailed pian enables signifi- cant deceleration of the disease progression that is now regarded as chronic, with life expectancy of the infected people similar to generál public.
The research continues and new developments in the area of biology and genetics of HIV (human immunodeficiency virus) make it possible both to disrupt its life cycle in new places and to impact the host immune mechanisms. Meidcinal products that activate the population of infected reservoir CD4+ T lymphocytes offer one opportunity.
Another possibility is wide-spectrum neutralizing antibodies capable of HIV binding from blood and flooded out from reservoirs. The results of clinical studies enable an introduction of new drugs and medicaijjrocedures.
Many countries regularly update their national recommended guidelines, just like the Czech Republic. The development of a universal vaccine has been in progress for more than 30 years, up tlil now unsuccess- fully.
There are many clinical studies focused on the development of both preventivě and therapeutic vaccines. Complex approach with antiretrovirals, HIV reservoir impacts and neutralizing antibodies could help reach the goal of World Health Organization - to eradicate HIV/AIDS to 2030.