Abstrakt
Equivalent to a thousandth of the diameter of a human hair, severe acute respiratory syndrome coronavirus 2 (SARS-CoV)-2 is an average size for an enveloped virus. Its structural proteins Spike, Envelope, and Membrane, embedded in a host-derived lipid edifice, enclose a nucleocapsid, holding one of the longest RNA viral genomes.Hijacking host translational machinery, this single-stranded genome encodes two polyproteins, with self-cleavagecapacity for release of 16 nonstructural proteins representing an enzymatic medley that forms an impressivearmoury.
While distinct from SARS-CoV and Middle East respiratory syndrome coronavirus, the SARS-CoV-2genome shares major identity with bat-SL-CoVZC45, although not enough for direct ancestry. A formidableinvader, SARS-CoV-2 binds to a constitutively expressed angiotensin-converting enzyme 2 receptor for multiorgan infection and host defence short-circuiting ability.
Harbouring one of the hardest coronavirus membrane proteins,this novel virion maintains exclusive resilience in bodily fluids and external environments, necessitating complexstrategies for its eradication