Abstract
New disinfectant compositions that are applicable to a range of hospital bacterial and fungal infections while limiting the emergence of resistance to disinfectants are the subject of a technical solution. To this end, a disinfecting composition containing quaternary ammonium salts has been developed, the essence of which is that it contains 1-hexadecylpyridinium bromide in combination with at least one quaternary ammonium salt selected from a group including 1-hexadecylpyridinium, 1-hexadecyl-3-(Z)-(hydroxyiminomethyl-pynium and 4-hexadecyl-4-(2-hydroxyethyl)morpholine-4-4-sodium.
The mass ratio between the various ammonium salts contained in the disinfection composition according to the technical solution is in the range 1:4 to 4:1, with an advantage of 1:2 to 2:1. In addition, according to the next implementation of the technical solution, the disinfection composition includes at least one excipient selected from the group containing perfumes, gel-forming agents, adhesive agents, dyes, or solvents.
According to a further technical solution, the disinfection composition is in the form of a solution, foam or gel. Desinfectious compositions according to the invention showed high disinfecting efficacy against Gram-negative and Gram-positive bacteria and selected pathogenic fungi that commonly cause nosocomial disease (Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Candida albicans, Aspergillus niger, Bacillus subtilis), as tested.
The disinfecting efficacy of prepared compositions according to the invention was comparable to benzyldodecyldimethylammonium bromide, which is the main active ingredient in a number of commonly available disinfectants based on quaternary ammonium salts. From the tests that were conducted, it turned out that the greatest efficacy was achieved for compounds with a C?16-member secondary chain.
The basic skeleton of the compound has a substantial effect on the efficiency spectrum. Therefore, a wide spectrum of activity against common hospital pathogens can be achieved by combining compounds with a different base skeleton.