Role of lomitapide in treatment of severe familial hypercholesterolaemia

Abstract

Homozygous familial hypercholesterolaemia is an autosomal-domininat inherited disease presenting with highly elevated low density lipoprotein cholesterol levels. Untreated, the patient can develop atherosclerosis and cardiovascular disease already in adolescence.

Treatment with statins and ezetimibe is usually not sufficient and LDL apheresis is often required.

Keywords

• lomitapide
• homozygous familial hypercholesterolemia
• safety
• efficacy
• cardiovascular disease