Evaluation of Volume Response of Low Grade Glioma to Radiochemotherapy treated for Inoperable Progression or Residual Tumor
Abstract
Aim: Evaluation of low-grade glioma clinical and volume response to concomitant and adjuvant chemo-radiotherapy. Material and methods: We describe a series of seven patients (five men and two women) with defined progression or an inoperable residual tumor after low-grade glioma surgery.
Tumor volume regression was evaluated by means of manual computer volumetry. Results: Using computerized volumetric quantification in our pilot set of patients, we observed mean 90% (73-100%) reduction in tumor volume on T1W MRIs and 73% (41-100%) reduction of tumor volume on T2W MRIs.
Following cancer treatment, regression of epileptic seizures occurred in three patients, Jacksonian sensory epileptic seizures stayed stable in one patient. Conclusion: Combined cancer treatment in patients with inoperable low-grade glioma WHO grade II with low proliferation activity could lead to substantial tumor volume regression in a significant proportion of patients.