Incidence of prostate cancer in radical cystoprostatectomy specimen. Histopathological characteristics of tumor and the influence of the method of histological processing on the occurrence of incidental prostate cancer
Abstract
Incidence of prostate cancer in radical cystoprostatectomy specimen. Histopathological characteristics of tumor and the influence of the method of histological processing on the occurrence of incidental prostate cancer.
Aim: Radical cystoprostatectomy (RCP) as a surgical procedure in the treatment of invasive bladder cancer requires a high degree of radicality. Surgical techniques sparing prostate apex or capsule involve the risk of residual urothelial carcinoma or incidental prostate cancer (IKP).
The aim of this work is to assess the occurrence, histopathological characteristics of IKP and the influence of the method of histological preparation processing on the occurrence of IKP. Material and methods: A group of 91 patients after RCP were evaluated retrospectively, with procedures performed from January 2009 to August 2019.
In 42 patients the prostate was evaluated by the block method, in 49 patients the whole-mount section (WMS). The work assessed the histopathological characteristics of IKP.
Criteria for non-significant IKP determination: Gleason score 7 and tumor signifikance (p = 0.012) and between number of tumors with volume <= 0.5 cm3 and tumor significance, 3 vs. 10 tumors (p = 0.0000). The median follow-up was 19.5 months, with no clinical manifestation of IKP and no need to start treatment.
Conclusion: In our cohort the method used to prepare a histological specimen has a significant effect. Using the WMS technique, the IKP capture was significantly higher.