Abstract
This work is created for education of laboratory professionals in routine clinical laboratories and deals with possibility applying the liquid biopsy in routine mode. The determination of circulating DNA (cfDNA, ctDNA) are main topics of liquid biopsy.
Low invasiveness and possibility of often using are big advantages of these tests. Liquid biopsy methods are part of the disruption and digitalization in the of the laboratory medicine.
Routine laboratories should be one tool of precision medicine and methods of liquid biopsy, based on genomic (PCR, NGS) methods are surely the part of this process. Important factor for adaptation liquid biopsy to routine work is development of CDx (companion diagnostics tests).
Problems of results harmonizing and comparability of these methods are mentioned by means of several cases.