Abstract
The prevalence of abnormal thyroid function is approximately 4 to 4.5% of the population but in certain groups (family burden, autoimmune diseases, pregnant and postmenopausal women), the incidence is higher; targeted examination of these groups reveals incidence of 15% or even more. The presentation and clinical course of thyroid diseases is highly variable, ranging from asymptomatic, indolent disease that may never require therapy to active disease that can lead to serious consequences.
In some people with autoimmune thyroid disease, the thyroid function remains normal for their entire life. However, due to special influences (i.e., biological treatment), malfunction may occur.
The genetic influence on thyroid disease was shown in four cases in one family. In another patient, the influence of biological treatment on thyroid function was demonstrated.
In high-risk patients, the examination of not only TSH but also thyroid autoantibodies is indicated. In case of deviation, annual surveillance is warranted.