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Nanoscale Dynamic Readout of a Chemical Redox Process Using Radicals Coupled with Nitrogen-Vacancy Centers in Nanodiamonds

Publikace na Přírodovědecká fakulta, Ústřední knihovna, 1. lékařská fakulta |
2020

Tento text není v aktuálním jazyce dostupný. Zobrazuje se verze "en".Abstrakt

Biocompatible nanoscale probes for sensitive detection of paramagnetic species and molecules associated with their (bio)chernical transformations would provide a desirable tool for a better understanding of cellular redox processes. Here, we describe an analytical tool based on quantum sensing techniques.

We magnetically coupled negatively charged nitrogen-vacancy (NV) centers in ranodiamonds (NDs) with nitroxide radicals present in a biomert polymer coating of the NDs. We demonstrated that the T1 spin relaxation time of the NV centers is very sensitive to the number of nitroxide radicals, with a resolution down to 10 spins per ND (detection of approximately 10-23 mol in a localized volume).

The detection is based on T1 shortening upon the radical attachment, and we propose a theoretical m odel describing this phenomenon. We further show that this colloidally stable, water-soluble system can be used dynamically for spatiotemporal readout of a redox chemical process (oxidation of ascorbic acid) occurring near the ND surface in an aqueous environment under ambient conditions.