Abstract
In the last two decades the number of drugs prescribed to the elderly is increasing steadilly. Polypharmacy, despite being beneficial in the treatment of multimorbid patients,confers also a risk such as drug-drug interactions, adverse drug events, inappropriate drug prescription, higher level of frailty and increased mortality in some studies.
Critical appraisal of prescribed and used medications is an integral part of daily clinical practice of the geriatrician.A novel term in geriatric pharmacotherapy is „deprescribing“ defined as a systematic reduction or withdrawal of drugs for which there is no indication, which are inappropriate in older patients or specifically in individual patient, drug duplicities and all other drugs which do not reflect treatment goals and patient´s values and preferences.In the review article, for the first time in the Czech literature, the deprescribing process and recommended tools are discussed and the algorhithm for deprescribing of PPI presented as an example.