Abstrakt
The endothelial glycocalyx (EG) plays an important role in the mechanotransduction of shear stress to endothelial cells in addition to its function as a natural barrier protecting the inner blood vessel wall. The major components of endothelial glycocalyx include glycoproteins and proteoglycans containing heparan sulphate, hyaluronate and glycosaminoglycan side chains.
Further, EG is influenced by the macromolecular composition of blood plasma and by ion content in infusion solutions, especially during fluid resuscitation treatment. The aim of this project was to develop a suitable method to test the effect of infusion solutions on the endothelial glycocalyx.