Abstract
General practitioners usually meet patients with recurrent episodes of disorders characterized as common cold disease. These disorders can be seen repeatedly or their course may be prolonged.
Repeated herpetic infections, tonsillitis, cough and urologic disorders are also the reason for frequent visits of general practitioners. Typical symptoms include fatigue, fever, non-specific arthralgia or myalgia or enlargement of lymph nodes.
Triggers can be viruses, bacterial or fungal infection but also lifestyle and psychosomatic problems. Recurrent infections are also symptoms of immunodeficiency.
Primary immunodeficiency as a common variable immunodeficiency can be firstly diagnose at adulthood. Secondary immunodeficiency accompanied more frequently patients with immunosuppressive therapy, oncologic treatment and others.