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Ventricular activation pattern assessment during right ventricular pacing: Ultra-high-frequency ECG study

Publication at Central Library of Charles University, Third Faculty of Medicine |
2021

Abstract

BACKGROUND: Right ventricular (RV) pacing causes delayed activation of remote ventricular segments. We used the UHF-ECG to describe ventricular depolarization when pacing different RV locations.

METHODS: In 51 patients, temporary pacing was performed at the RV septum (mSp); further subclassified as RVIT and RVOT for septal inflow and outflow positions (below or above the plane of His bundle in RAO), apex, anterior lateral wall, and at the basal RV septum with nonselective His bundle or RBB capture (nsHBorRBBp). The timings of UHF-ECG electrical activations were quantified as: left ventricular lateral wall delay (LVLWd; V8 activation delay), RV lateral wall delay (RVLWd; V1 activation delay.

RESULTS: The LVLWd was shortest for nsHBorRBBp (11 ms (95% CI; 5;17), followed by the RVIT (19 ms (11;26) and the RVOT (33 ms (27;40), (p<0.01 between all of them), although the QRSd for the latter two were the same (153 ms (148;158) vs. 153 ms (148; 158); p=0.99). RV apical capture not only had a longer LVLWd (34 ms (26;43) compared to mSp (27 ms (20;34), p<0.05), but its RVLWd (17 ms (9;25) was also the longest compared to other RV pacing sites (mean values for nsHBorRBBp, mSp, anterior and lateral wall captures being below 6 ms), p<0.001 compared to each of them.

CONCLUSIONS: RVIT pacing produces better ventricular synchrony compared to other RV pacing locations with myocardial capture. However, UHF-ECG ventricular dysynchrony seen during RVIT pacing is increased compared to concomitant capture of basal septal myocytes and His bundle or proximal right bundle branch.