The pharmacological treatment of the late-life depression II: the use of antidepressants and their augmentations, treatment - resistant late-life depression
2021
Abstract
Major depressive disorder is common in adults aged 65 years and older, leading to disability, suicidality, and increased mortality, but can be mitigated by treatment. Antidepressants remain mainstay of the treatment.
The authors summarize findings of metaanalyses of antidepressant efficacy a tolerability from the last two decades. They also comment available data on treatment of resistant late-life depression and current treatment guidelines.