Abstrakt
Chronic kidney disease and non-alcoholic fatty liver disease are global public health concerns. Diabetes, hypertension, and obesity are risk factors for and major contributors to these diseases.
Common obesity is frequent in developed countries and is accompanied by chronic metabolic changes. Adipose tissue is the largest endocrine organ in the body, and expansion of this organ results in gradual but extensive cardiometabolic changes due to insulin resistance, proinflammatory status, and endothelial dysfunction, with irreversible central dysregulation of energy homeostasis.
The renal and liver effects of common obesity may have their origins in childhood overweight.