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Eosinophilic myocarditis as a manifestation of eosinophilic granulomatosis with polyangiitis

Publikace na 2. lékařská fakulta |
2020

Tento text není v aktuálním jazyce dostupný. Zobrazuje se verze "en".Abstrakt

We present a case- clinical presentation, diagnosis, management and follow up of a 36-year-old woman with acute myocarditis as a manifestation of eosinophilic granulomatosis with polyangiitis (EGPA). The patient with a history of asthma and allergies presented with clinical signs of acute myocarditis and with peripheral eosinophilia in blood, an endomyocardial biopsy was then performed with histological proof of necrotizing eosinophilic myocarditis.

EGPA is one of the various causes of hypereosinophilic syndromes. It is a rare multisystemic autoimmune disorder and cardiac involvement can represent one of its components.

The suspicion should be raised in patients with symptoms and signs of myocarditis and/or pericarditis or heart rhythm abnormalities with eosinophilia in blood count, with a history of asthma, allergic rhinitis, abnormalities in the paranasal sinuses and neuropathy. Treatment of EGPA requires immunosuppression mainly with glucocorticoids, but other agents, such as azathioprine, can be also considered.