The COVID-19 pandemic reached the Czech Republic in March 2020, leading to three national lockdowns over the following 12 months. We analysed monthly diagnoses of gonorrhoea and syphilis in a large tertiary care centre in Prague during March 2020-February 2021 relative to the monthly average of the previous 4 years (March 2016-February 2020).
After an initial slight decrease, there was an increase in confirmed cases of early syphilis in the second half of 2020. These results differ from those described in some other European countries.
The increase in early syphilis cases may reflect non-compliance with social distancing restrictions, as suggested by the marked increase in COVID-19 cases reported in the Czech Republic in the same period.