Abstract
The results of multicenter randomized and controlled clinical trials, which were published in 2018 and 2019, showed the efficiency and safety of intravenous thrombolysis in the treatment of acute ischemic stroke in selected patients even beyond the standard therapeutic time window, and in those with unknown time of ischemic stroke onset. Based on this scientific evidence, the availability of specific antidotes for direct anticoagulants and the publication of new recommendations of the European Stroke Organisation and the American Heart Association/American Stroke Association, an update of the Czech national guidelines on the treatment of acute ischemic stroke with intravenous thrombolysis from the year 2014 became necessary.
These recommendations do not substitute the valid legislative norms and represent a consensual statement of the Executive Committee of the Czech Stroke Society (a part of the Czech Neurological Society of the Czech Medical Association J. E.
Purkyně).