Abstract
Diabetes mellitus is a civilization disease and can lead to the development of serious late complications such as diabetic nephropathy, which is one of the main causes of terminal renal failure. The aim of this study was to study magnesium deficiency, which would be a possible marker of diabetic nephropathy.
Furthermore, the study also examines the hydration state of patients with diabetes mellitus. A monocentric, prospective, open cohort study was performed in 258 patients diagnosed with diabetes mellitus.
A statistically significant difference (p = 0.013) in the Mg/Creatinine ratio in magnesium deficiency was demonstrated between diabetics with positive and negative microalbuminuria. Moreover, it has been shown that magnesium deficiency increases with age, this trend is more pronounced in diabetics with positive microalbuminuria.
The hydration state of the studied group of patients was evaluated on the basis of urine osmolality and in most of these patients it was in the reference range. Dehydration was demonstrated in only 2.3% of patients.