Molecular component diagnostics in analysis of sensitizacion to food and aeroallergens in atopic dermatitis patients
Abstract
Abstract The aim of this study was to analyse the sensitization to molecular components in atopic der-matitis patients (according to the severity of AD and according to the occurrence of allergic rhinitis and asthma bronchiale). Altogether 104 atopic dermatitis patients (50 men, 54 women) at the average age 40.1 years were examined.
The highest observed sensitization rate was 61.0 % to grass specific molecule Phl p 1, the second most frequent sensitization was 57. 0 % to Betulaceae-specific molecule Bet v 1. Frequently observed sensitizations were those to PR-10 proteins, NPC2 proteins family, Uteroglobin and Lipocalin.
We have confirmed the significant differences in the sensitization to molecular components in patients suffering from severe form of AD, and in subgroups of patients suffering from AB and AR.Fundamental position have the components Phl p 1 (Timothy), Bet v 1 (Birch), Alt a 1 (Alternaria) followed by molecular components of NPC2 family, cystein proteasa, tropomyosin, uteroglobin, lipocalin and PR-10 protein.