Abstract
Multiple sclerosis is a chronic autoimmune disease of the central nervous system requiring early diagnosis and treatment. Currently, there is no specific test to confirm the diagnosis of multiple sclerosis.
Therefore, the diagnostic process continues to be based on three main principles: clinical analysis compatible with the diagnosis (type of symptoms, their progression in time, the person's age and sex, etc.), evidence of process dissemination in time and space, and exclusion of alternative diagnoses. Given the importance of early diagnosis, the diagnostic criteria were revised in 2017, again highlighting the importance of detecting intrathecal oligoclonal band synthesis.
Newly, the presence of oligoclonal bands can replace dissemination in time in establishing the diagnosis. These changes should facilitate establishing early diagnosis that can be followed by immediate treatment.