Publication at Second Faculty of Medicine |
2021
Abstract
KMT2A-CBL rearrangements are rare events identified in leukemias of various lineages. Conventional cytogenetics may miss such rearrangements but the increasingly widespread use of targeted sequencing techniques in the diagnostic work-up will probably increase the number of cases identified.
International collaborative efforts are necessary to improve the characterization of the KMT2A-CBL rearrangement and investigate its prognostic impact. Ultimately, functional experiments of KMT2A-CBL gain-of- function models and CD34+ hematopoietic progenitor cell may provide fundamental knowledge about the leukemogenic potential and the cell-of-origin of KMT2A-CBL leukemias.