Easy and fast PCR-based protocol allows characterization of breakpoints resulting from Alu/Alu-mediated genomic rearrangements

Abstract

In summary, we present a PCR-based protocol that allows direct and fast mapping of even very complex Alu/Alu-mediated rearrangements. We believe this method may substantially facilitate nucleotide level molecular diagnostics as well as family screening/counselling.

Keywords

• alu
• sequences
• evolution