Parkinson's disease is the second most common neurodegenerative disease, with an increasing trend worldwide. One of the characteristic motor manifestations of the disease is continuous and episodic gait disorders, which affect the lives of up to 89% of all patients with Parkinson's disease.
Freezing is an episodic gait disorder characterized as sudden cessation of movement and an inability to take an effective step. Cueing therapy is a worldwide known and used therapy for acute freezing, which uses external stimuli to facilitate movement.
Although the clinical efect of cueing has been described in a number of studies, its mechanism of action has not been fully elucidated.