Effects of synthetic cathinone naphyrone in the conditioned place preference test - evidence of its addictive potential
Abstract
Naphyrone, also known as NRG-1, is a novel psychoactive substance (NPS), a cathinone with stimulatory properties available on the grey/illicit drug market for almost a decade. It is structurally related to infamously known powerful stimulants with the pyrovalerone structure, such as alpha-pyrrolidinovalerophenone (α-PVP) or methylenedioxypyrovalerone (MDPV) that are labeled as a cheap replacement for cocaine and other stimulants.
Despite the known addictive potential of α-PVP and MDPV, there are no studies directly evaluating naphyrone's addictive potential e.g., in conditioned place preference (CPP) test or using self-administration. Therefore, our study was designed to evaluate the addictive potential in a CPP test in male Wistar rats and compare its effect to another powerful stimulant with a high addictive potential - methamphetamine.
Naphyrone increased time spent in the drug-paired compartment with 5 and 20mg/kg s.c. being significant and 10mg/kg s.c. reaching the threshold (p = 0.07); the effect was comparable to that of methamphetamine 1.5mg/kg s.c. The lowest dose, naphyrone 1mg/kg s.c., had no effect on CPP.
Interestingly, no dose response effect was detected. Based on these data, we are able to conclude that naphyrone has an addictive potential and may possess a significant risk to users.