Publication at Faculty of Science, First Faculty of Medicine, Faculty of Medicine in Hradec Králové |
2021
Abstract
Familial hypercholesterolemia, is an autosomal dominant disorder caused by mutations in the LDLR, APOB, PCSK9, and APOE genes and is characterized by high plasma levels of total and low-density lipoprotein (LDL) cholesterol. Our study aimed to analyze the influences of two different therapies on a wide spectrum of plasma protein biomarkers of cardiovascular diseases.
Plasma from FH patients under hypolipidemic therapy and patients under combined long-term LDL apheresis/hypolipidemic therapy were analyzed in our study. We measured a profile of 184 cardiovascular diesase associated proteins using a proximity extension assay.