Abstract
In this article, we will look at discoveries and hypotheses that were through time linked to Alzheimer's-Fischer disease, mainly in the con- text of pathophysiology. As part of the understanding of the link, pathological findings are mentioned first, as on the basis of these, the hypotheses were gradually developed.
However, given the enormous scale, we have tried to select only some of the hypotheses that are most frequently mentioned or, from our point of view, the most interesting. Our goal is not to map in detail all of modern history, so we will move directly from the beginning of the 20th century to its second half.
Dementia gradually became a growing medical and social problem during this period, while technological possibilities opened up new avenues of research.