Ligand-dependent stereoselective Suzuki-Miyaura cross-coupling reactions of β-enamido triflates

Abstrakt

The stereoselective Suzuki-Miyaura cross-coupling of (Z)-β-enamido triflates is demonstrated. Depending on the nature of the ligand in the palladium catalyst, either retention or inversion of the configuration during the synthesis of β,β-diaryl-substituted enamides is observed.

Thus, the method provides synthetic access to both isomers of the target enamides from (Z)-β-enamido triflates.

Klíčová slova

• enamides
• isomerization
• Suzuki-Miyaura coupling
• vinyl triflates