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Perinatal outcome of SARS-CoV-2 infection in pregnancy

Publication at Third Faculty of Medicine |
2022

Abstract

SARS-CoV-2 placentitis is a rare and serious complication of COVID-19 disease in pregnancy. The coronavirus placental infection may lead to maternal and fetal vascular malperfusion (pregnancy itself is a prothrombotic state), fetal demise, intrauterine hypoxia, fetal growth restriction, or preterm birth with the accompanying neonatal morbidity.

In case of transplacental transmission of SARS-CoV-2, newborns can also suffer from early-onset viral pneumonia. Consequently, comprehensive epidemiology control should be implemented during pregnancy (frequent testing, contact tracing, vaccination).

Furthermore, anticoagulation prophylaxis (low-molecular-weight heparin) and thorough fetal surveillance may be employed in COVID-positive pregnancies, especially in highrisk cases with preexisting placental insufficiency.