Abstract
Teduglutide therapy in patients with short bowel syndrome Short bowel syndrome (SBS) is defined as malabsorption resulting from anatomical loss of a significant length of the small intestine, that is unable to provide the body's nutritional needs. A completely new therapeutic option for patients with SBS is a pharmacological support of intestinal adaptation by the administration of teduglutide - an analogue of glucagon-like peptide 2 (GLP-2).
The article describes current knowledge about the effects of teduglutide, summarizes the indications, contraindications, side effects of treatment and current consensual recommendations for monitoring of patients during therapy. The goal of treatment with teduglutide is the reduction of the volume and caloric content of parenteral nutrition (PN), which leads to reduction in PN complications.
In some patients the treatment may allow PN weaning. The reduction of PN volume is also associated with an improvement in the quality of life of patients and their parents.