Publication at Faculty of Science, Central Library of Charles University |
2021
Abstract
We developed a multifunctional polymer coating for nanoparticles (NPs) that enables simultaneous detection by (19)F MRI and shielding from blood plasma fouling. The coating is based on a water-soluble fluorinated poly(N-(2-fluoroethyl)acrylamide) (PFEAM) that shows high (19)F MRI sensitivity, cytocompatibility and excellent antifouling properties, significantly outperforming polyethylene glycol.
A proof-of-concept experiment was performed by synthesizing polymer-coated gold NPs that were successfully visualized by (19)F MRI at magnetic fields close to the fields used in clinical practice. This universal approach can be used for coating and tracing of various NPs upon suitable polymer chain-end modification.