Abstract
Patients with relapsed/refractory non-Hodgkin B-cell lymphomas suffer from a very poor survival. Chimeric antigen receptor T-cells (CAR-T) offer an attractive treatment approach using autologous genetically modified immune-effector cells.
Main advantages include good treatment response, short-term and predictable toxicity profile, and prolonged survival. This review summarizes clinical trials with axicabtagene ciloleucel (axi-cel, Yescarta), published results, and real-world experience including first Czech data.