Diabetes mellitus means presence of chronic hyperglycaemia caused by many external and internal conditions. The most frequently present type is Type 2 diabetes.
In its pathogenesis play important role insulin resistance and disturbance of insulin secretion. Diabetic patients are extremely risky in development of macrovascular complications and diabetes is considered to be an equivalent of present cardiovascular disorder.
In treatment of diabetes we start with lifestyle changes, weight reduction and metformin at the same time. In not optimal metabolic compensation, we add to metformin another drug or insulin.