Gliflozins are well known oral hypoglycaemic agents, which were recently approved also for heart failure and renal insufficiency treatment. This case report describes a traditional scenario where gliflozin is the rational choice of therapy in a patient with uncontrolled diabetes and a history of ischaemic heart disease with heart failure, leading to early improvement of diabetes control and also long-term reduction of cardiovascular risk in a high-risk polymorbid patient.